MeTis Lipid 1
Version 1.3aa5e3ee · 2026-09-13
| CAS No. | Not available |
| Chemical Name | MeTis Lipid 1 |
| Synonyms | MeTis Lipid-1 |
| SMILES | CCCCCCCCCC(=O)OCC(C)(C)CCCCC(CCCCC(C)(C)COC(=O)CCCC(CCCCC)CCCCC)OC(=O)CCCN(C)C |
| Formula | C48H93O6N |
| M.Wt | 780.27 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
MeTis Lipid 1 is an ionizable lipid featuring a pentacyclic core with geminal dimethyl groups and symmetrical C9 alkyl chains developed by Metis Pharm. According to Patent WO 2025/140421 A1, Lipid 1 demonstrated exceptional biological performance including: the highest SARS-CoV-2 neutralization titer (NT50 1:2146, 5.7-fold higher than ALC0315), potent humoral immunity with COVID-19 IgG titers reaching 1:1,000,000 post-boost and exclusive validation for VZV-gE IgG (1:1,000,000), favorable biophysical properties (124.5 nm LNP diameter, 0.2 PDI, 85% encapsulation efficiency), and excellent safety profile (hERG IC₅₀ >30 μM, Mini-Ames negative), establishing it as the lead compound in nucleic acid vaccine delivery.
Specifications shown are product-page values, not batch test results.
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