Lipid CDL9
Version 1.fc2d604f · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid CDL9 |
| Synonyms | Lipid-CDL9 |
| SMILES | CCCCCCCCCCCCCCCCCCCC(=O)OCCN(CCOC(=O)CCCCCCCCCCCCCCCCCCC)CCOC(=O)CCCCC1CCSS1 |
| Formula | C54H103O6NS2 |
| M.Wt | 926.54 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
CDL9 is an original cyclic disulfide lipid first designed, synthesized, and functionally validated in the study "In Vivo Demonstration of Enhanced mRNA Delivery by Cyclic Disulfide-Containing Lipid Nanoparticles for Facilitating Endosomal Escape" published in RSC Medicinal Chemistry (DOI: 10.1039/D5MD00084J).Its molecular architecture—featuring a C18:2 di-unsaturated alkyl chain linked to a tertiary amine headgroup modified with an α-lipoic acid-derived cyclic disulfide unit—was explicitly detailed in the paper's lipid library. Experimental data from this study demonstrated CDL9’s capacity to boost mRNA delivery efficiency by 6-fold in vitro and 5-fold in vivo when integrated into SM102-based LNPs, leveraging thiol-disulfide exchange for enhanced endosomal escape.
Specifications shown are product-page values, not batch test results.
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