ORNA lipid 144（1-C）
Version 1.170fff47 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | ORNA lipid 144（1-C） |
| Synonyms | ORNA lipid-144，lipid 144，lipid144 |
| SMILES | CCCCCCCC(CCCCC)CCC(=O)OCCCCCCN(CCCCCO)C[C@H](O)CCCCOC(=O)CCC(CCCCC)CCCCCCC |
| Formula | C49H97O6N |
| M.Wt | 796.32 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
ORNA lipid 144 is a novel ionizable lipid engineered for splenic RNA delivery developed by ORNA Therapeutics, featuring a biodegradable structure with a protonatable tertiary amine headgroup and ester-linked branched C14 alkyl chains. This design enables exceptional spleen-targeting capability, demonstrated by 3-fold higher luciferase expression in the spleen compared to benchmark lipids and near-complete B-cell depletion when delivering anti-CD19 CAR circRNA. It forms highly stable lipid nanoparticles maintaining homogeneous size (60–80 nm) and low polydispersity across diverse manufacturing conditions and buffer systems. Rapid clearance from the liver and spleen minimizes off-target accumulation, while high circRNA encapsulation efficiency (>90%) and pH-dependent endosomal escape make it ideal for immunotherapies and vaccines requiring precise splenic bioavailability and sustained efficacy.
Specifications shown are product-page values, not batch test results.
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