ATX L1
Version 1.c27808af · 2026-09-13
| CAS No. | Not available |
| Chemical Name | ATX L1 |
| Synonyms | ATX-L1， ATXL1 |
| SMILES | CCCCCCCC(CCCCCCC)OC(=O)CCCN(CCCC(=O)OC(CCCCCCC)CCCCCCC)C(=O)OCCSSCCCN(C)C |
| Formula | C46H90O6N2S2 |
| M.Wt | 831.35 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Design and Evaluation of Biodegradable Self-Immolative Lipids for RNA Delivery-R Mukthavaram, A Sagi, H Hong, R Recatto… - Advanced healthcare materials |
L1 is a biodegradable, branched self-immolative lipid optimized for high-efficiency mRNA delivery. Its disulfide-based architecture enables rapid glutathione-triggered degradation in the cytosol (liver half-life: 4.2 days), promoting rapid clearance while maintaining serum stability. In vivo, L1 achieves exceptional mRNA translation, producing twice the hEPO protein levels of the clinically approved MC3 lipid at 0.1 mg/kg. Its apparent pKa (6.57) facilitates efficient endosomal escape without compromising safety: even at 5 mg/kg, L1 causes no significant body weight loss or sustained inflammation. Structural features (C7 alkyl tails, carbamate linker) balance potency and biodegradability, making L1 ideal for mRNA vaccines and protein-replacement therapies.
Specifications shown are product-page values, not batch test results.
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