Yoltech lipid 4
Version 1.0017f4fa · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Yoltech lipid 4 |
| Synonyms | Yoltech lipid-4 |
| SMILES | CC/C=C\CCCCOC(CCC(=O)OCCCN(C(=O)CCN(CC)CC)C(CCCCCCCCC(=O)OCC(CCCC)CCCCCC)C(=O)NCCCCCCCC)OCCCC/C=C\CC |
| Formula | C61H115O8N3 |
| M.Wt | 1,018.60 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
Yoltech lipid 4, a highly efficient ionizable lipid disclosed in patent PCT/CN2023/116607, features a central tertiary amine group flanked by hydrophobic tails—specifically, a bis(2-ethylhexyl) core and a linoleyl (C18:2) chain linked via ester bonds. This structure enables pH-responsive behavior critical for mRNA/LNP delivery: neutral in circulation (reducing toxicity) but protonated in endosomes to facilitate membrane disruption and payload release. In murine studies targeting liver PCSK9, Compound 4 achieved ~90% gene-editing efficiency. Its optimized formulation yields LNPs of 70–150 nm with >90% encapsulation, ideal for hepatocyte-specific delivery.
Specifications shown are product-page values, not batch test results.
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