DC67520 · Updated 28 October 2026

nor-MC3

Product Datasheet

nor-MC3 is an ionizable lipid evaluated in liposomal LNPs for extrahepatic mRNA delivery. The 2025 study combines nor-MC3 with egg sphingomyelin, cholesterol and PEG-DMG, and reports prolonged circulation and increased reporter expression in selected extrahepatic tissues relative to an MC3-based comparator. The findings apply to the tested formulations rather than isolated nor-MC3.

CAS No.	Not available
Chemical Name	nor-MC3
Synonyms	norMC3， nor MC3
SMILES	CCCCC/C=C\C/C=C\CCCCCCCC(CCCCCCC/C=C\C/C=C\CCCCC)OC(=O)CCCN(C)C
Formula	C41H75O2N
M.Wt	614.06
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Cheng MHY et al. Liposomal lipid nanoparticles for extrahepatic delivery of mRNA. Nature Communications 16, 4135 (2025). DOI: 10.1038/s41467-025-58523-w. Supporting Information: Table S1 and Figures S2-S13. Related reference: Arnold D et al. nor-MC3 and nor-KC2: cationic ionizable lipids for the delivery of therapeutic nucleic acids. RSC Pharmaceutics 3, 654-658 (2026). DOI: 10.1039/D5PM00350D.

Research evidence

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Specifications are catalog specifications, not batch test results.