PRODUCT DATASHEET · DC67453
Lipid 114
Version 1.f9f60f89 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid 114 |
| Synonyms | ditetradecyl 4,8,17-tris(3-oxo-3-(tetradecyloxy)propyl)-4,8,13,17-tetraazaicosanedioate,Lipid-114 ,Lipid114 |
| SMILES | CCCCCCCCCCCCCCOC(CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCNCCCCN(CCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)=O |
| Formula | C95H186N4O10 |
| M.Wt | 1,544.5 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
Lipid 114 (pKa ~6.8) is an ionizable cationic lipid optimized for siRNA delivery via LNPs, demonstrating predominant hepatic accumulation with secondary renal uptake in murine models. When formulated with IL-1β-targeting siRNA, these LNPs effectively suppress pro-inflammatory cytokine expression in both macrophage cell lines and primary cells in a dose-dependent manner. In LPS/galactosamine-induced acute liver failure models, the therapeutic LNPs significantly reduce IL-1β levels in target organs while attenuating hepatic inflammation and injury markers.
Specifications shown are product-page values, not batch test results.
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