PRODUCT DATASHEET · DC67452
Lipid PPz-2R1
Version 1.60b323ae · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid PPz-2R1 |
| Synonyms | Lipid PPz 2R1 piperazine-1,4-diylbis(hexane-6,1-diyl) bis(2-hexyldecanoate) |
| SMILES | O=C(C(CCCCCC)CCCCCCCC)OCCCCCCN1CCN(CCCCCCOC(C(CCCCCCCC)CCCCCC)=O)CC1 |
| Formula | C48H94N2O4 |
| M.Wt | 763.3 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
PPz-2R1 is an ionizable cationic lipid engineered for mRNA delivery via lipid nanoparticles (LNPs). These LNPs demonstrate remarkable lung-selective accumulation in mice, showing significantly higher uptake compared to heart, liver, spleen, and kidney tissues. When loaded with PTEN mRNA, PPz-2R1 LNPs effectively restore tumor suppressor function in PTEN-deficient lung cancer cells and inhibit tumor progression in orthotopic models, with enhanced efficacy observed in combination with PD-1 blockade therapy.
Specifications shown are product-page values, not batch test results.
Read Instructions for Use →