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Instructions for Use — 9C-SCC-10
DC67451 · Updated 18 October 2026
Description:
9C-SCC-10 is a biodegradable ionizable lipid with a nine-membered triaza crown-like headgroup and three disulfide-containing hydrophobic arms. In the cited mouse study, LNPs containing uncomplexed 9C-SCC-10 showed liver-biased mRNA-derived expression and an apparent LNP pKa of 6.42. Coordination with zinc produced the distinct Zn-9C-SCC-10 system, which shifted expression toward the lung. DC67451 refers to the uncomplexed lipid; the zinc-coordinated formulation is described separately in the literature analysis.
Chemical Information
| Parameter | Value |
|---|---|
| Catalog number | DC67451 |
| Chemical Name | 9C-SCC-10 |
| CAS No. | Not available |
| Synonyms | 9CSCC10; 9C SCC 10; 9C-SCC10; 9C crown-like biodegradable ionizable lipid |
| Formula | C69H129N3O12S9 |
| M.Wt | 1481.40 |
| SMILES | CCCCCCCCCCSCC(C)C(=O)OCCSSCCOC(=O)CCN1CCN(CCC(=O)OCCSSCCOC(=O)C(C)CSCCCCCCCCCC)CCN(CCC(=O)OCCSSCCOC(=O)C(C)CSCCCCCCCCCC)CC1 |
| Purity | >95% by ELSD-HPLC |
| Storage | −20 °C; unopened, protected from light and moisture. Follow the supplied batch expiry/retest date. |
| Publication | Chen, Z.; Yang, Y.; Qiu, X.; Zhou, H.; Wang, R.; Xiong, H. Crown-like Biodegradable Lipids Enable Lung-Selective mRNA Delivery and Dual-Modal Tumor Imaging In Vivo. J. Am. Chem. Soc. 2024, 146 (49), 34209–34220. DOI: 10.1021/jacs.4c14500 |
Handling:
Store the unopened product at −20 °C, protected from light and moisture, with the vial tightly sealed. The standard storage period is 1 year; follow the expiry or retest date on the supplied batch documentation. Allow the closed vial to reach room temperature before opening to avoid condensation.
We ship the pure lipid with ice packs, without ethanol. Prepare an ethanol stock solution when required. Gentle warming and brief sonication may assist dissolution; confirm complete dissolution at the intended concentration.
Prepare and use solutions on the same day wherever possible. If advance preparation is required, use a validated storage procedure and tightly sealed aliquots. A general solution shelf life is not assigned.
For small amounts of oily or viscous lipid, dissolve the entire pack and take volumetric aliquots. For example, dissolve 25 mg and adjust to a final volume of 1 mL to obtain 25 mg/mL; a 100 µL aliquot contains 2.5 mg.
Product-specific stock-solution stability is not established. The material is the uncomplexed parent; zinc coordination is a separate preparation. Disulfide linkages can be altered under reducing conditions.
Formulation & Performance:
The uncomplexed and zinc-coordinated systems are documented separately. The optimized zinc formulation uses Zn-9C-SCC-10 / DOPE / cholesterol / DMG-PEG2000 at 30:15:30:3 molar parts. N/P and the isolated zinc-complex molecular weight remain unresolved.
Read detailed preparation, mass conversions, study results and references →
References:
Chen, Z.; Yang, Y.; Qiu, X.; Zhou, H.; Wang, R.; Xiong, H. Crown-like Biodegradable Lipids Enable Lung-Selective mRNA Delivery and Dual-Modal Tumor Imaging In Vivo. J. Am. Chem. Soc. 2024, 146 (49), 34209–34220. DOI: 10.1021/jacs.4c14500.