PRODUCT DATASHEET · DC67450
A28-C6B2
Version 1.adf9b5d4 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | A28-C6B2 |
| Synonyms | A28C6B2， A28 C6B2 |
| SMILES | CCCCCCC(COC(CCCCCN(CCCCCC(OCC(CCCC)CCCCCC)=O)CCCCCO)=O)CCCC |
| Formula | C41H81NO5 |
| M.Wt | 668.1 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Ren, Y., Zeng, L., Tang, Y., et al. Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles. J. Mater. Chem. B. |
A28-C6B2 is a biodegradable ionizable lipid specifically engineered for spleen-targeted delivery. Through its unique branched structure, it bypasses hepatic uptake to achieve highly efficient transfection of F4/80+ macrophages and CD11c+ dendritic cells within the spleen. This lipid remains neutral in the bloodstream to minimize non-specific interactions, while undergoing protonation in the acidic environment of the endosome to facilitate nucleic acid release, thereby significantly enhancing the potency of mRNA vaccines and immunotherapies.
Specifications shown are product-page values, not batch test results.
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