PRODUCT DATASHEET · DC67449
Lipid TG4C
Version 1.a1bedfac · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid TG4C |
| Synonyms | Lipid-TG4C |
| SMILES | CN(C)CCCC(OC(COC(CCCCC(OC(CCCCCCCC)CCCCCCCC)=O)=O)COC(CCCCC(OC(CCCCCCCC)CCCCCCCC)=O)=O)=O |
| Formula | C55H103NO10 |
| M.Wt | 938.4 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
TG4C is an ionizable cationic lipid (pKa 6.71) optimized for mRNA delivery via lipid nanoparticles (LNPs). When formulated into LNPs carrying human EPO mRNA, it significantly elevates serum EPO levels in mice. Furthermore, aerosolized TG4C-based LNPs containing HGF mRNA demonstrate therapeutic potential in pulmonary emphysema models, showing reduced inflammatory cytokines (IL-1β, IL-6, TNF-α) in bronchoalveolar lavage fluid after elastase-induced lung injury.
Specifications shown are product-page values, not batch test results.
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