Merck Lipid X (L608, Merck-32)
Version 1.914378c9 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Merck Lipid X (L608, Merck-32) |
| Synonyms | Not available |
| SMILES | Not available |
| Formula | Not available |
| M.Wt | Not available |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale-J Cell Biol. 2021 Dec 9;221(2):e202110137. doi |
L-608 is a novel ionizable amino lipid designed for formulating lipid nanoparticles (LNPs) to enable efficient subcutaneous (s.c.) delivery of mRNA therapeutics. Engineered to address inflammation associated with mRNA LNPs, L608 integrates seamlessly with steroid prodrugs, such as budesonide-C16 and budesonide-C18:1, to suppress local and systemic inflammatory responses while prolonging therapeutic protein expression. Preclinical studies demonstrate that L608 LNPs significantly reduce injection-site edema (>80% improvement) and lower systemic inflammatory markers (e.g., haptoglobin), while achieving 2–3× higher plasma AUC for proteins like hFGF21 compared to non-steroid LNPs.
Specifications shown are product-page values, not batch test results.
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