YHS-12
Version 1.b29e3c4b · 2026-09-13
| CAS No. | Not available |
| Chemical Name | YHS-12 |
| Synonyms | YHS12， YHS 12 |
| SMILES | CCCCCCCCCCCCN(CCNC(/C=C/C(NCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)=O)CCCCCCCCCCCC |
| Formula | C56H112N4O2 |
| M.Wt | 873.5 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
YHS-12 is an ionizable cationic lipid (pKa = 6.506) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo.1 LNPs containing YHS-12 and the macrophage targeting peptide CRVLRSGSC and encapsulating mRNA encoding chimeric antigen receptor targeting methicillin-resistant S. aureus (MRSA) and siRNA targeting caspase-11 increase the phagocytosis rate of MRSA in RAW 264.7 macrophages and primary mouse bone marrow-derived macrophages (BMDMs). Intravenous administration of these LNPs decreases blood bacterial burden and increases survival in a model of sepsis using cyclophosphamide-induced immunosuppressed mice.
Specifications shown are product-page values, not batch test results.
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