Lipid 11-A-M
Version 1.9ccb9bca · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid 11-A-M |
| Synonyms | Lipid 11AM， Lipid 11 A M |
| SMILES | CCN(CC)CCCOC(OCC(COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(C[C@@]12CC3C[C@H](C[C@@H](C3)C2)C1)=O)=O |
| Formula | C42H71NO7 |
| M.Wt | 702.02 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Lokugamage, M. P., Sago, C. D., Gan, Z., Krupczak, B. R., & Dahlman, J. E. (2019). Constrained nanoparticles deliver siRNA and sgRNA to T cells in vivo without targeting ligands. Advanced Materials, 31(41), e1902251. doi.org |
Lipid 11-A-M (LNP Lipid-8) is a specialized single-tail, multi-head ionizable cationic lipid engineered for targeted nucleic acid delivery to T cells. Unlike traditional lipids that exhibit strong liver tropism, 11-A-M formulations successfully bypass hepatocytes, resulting in negligible liver accumulation and toxicity. Upon intravenous administration, it naturally localizes to peripheral immune organs, enabling robust gene silencing and transfection specifically within splenic CD3⁺ T cells, with a higher efficiency in CD8⁺ cytotoxic T cells over CD4⁺ helper T cells. This liver-evading, T cell-specific targeting profile makes it a premier tool for in vivo immunotherapy and in situ cell reprogramming.
Specifications shown are product-page values, not batch test results.
Read Instructions for Use →