PRODUCT DATASHEET · DC60964
TTP-3
Version 1.d63e76c5 · 2026-09-13
| CAS No. | Not assigned |
| Chemical Name | TTP-3 |
| Synonyms | Not reported |
| SMILES | CCCCC/C=C\C/C=C\CCCCCCCC(=O)N(CCCN(C)C)C(C(=O)NCCCCCCOC(=O)C(CCCCCC)CCCCCCCC)C(C)(C)C Structure-derived from the alkene geometry drawn in the cited publication; absolute stereochemistry is not specified. |
| Formula | C 51 H 97 N 3 O 4 (calculated from the literature-reported structure) |
| M.Wt | 816.35 g/mol (calculated) |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Pure lipid, shipped from Shanghai with ice packs. |
| Publication | Chen J, Zhou M, Dong S, et al. Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis. Science . 2026;393:eaeb0054. DOI: 10.1126/science.aeb0054 |
TTP-3 is an asymmetric Ugi-derived ionizable lipid identified from a 1,000-member library designed for pulmonary delivery of structured suppressor tRNA. In the cited study, TTP-3 was selected in a cystic-fibrosis-relevant air–liquid interface model containing artificial mucus, then evaluated in optimized LNP formulations for intratracheal delivery. All formulation and performance data below are literature-reported and remain specific to the stated cargo, preparation process, dose, model and administration route.
Specifications shown are product-page values, not batch test results.
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