FL0445
Version 1.6881264e · 2026-09-13
| CAS No. | Not available |
| Chemical Name | FL0445 |
| Synonyms | FL0445,FL-0445,FL 0445 |
| SMILES | CCCCCCCCCC(=O)OCCN(CCN(CC)CC)CCOC(=O)OC(CCCCC)CCCC(=O)OCC(CCCCC)CCCCC |
| Formula | Not available |
| M.Wt | Not available |
| Purity | 98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Kimura S, Tsutsumi S, Nakamura N, Tsujihata S, Fangjie L, Nakashima Y, Kita S, Maenaka K, Hashiya F, Inagaki M, Abe N, Kimura Y, Abe H. A branched ionizable lipid nanoparticle platform for versatile in vivo delivery of nucleic acids: Validation from mRNA to capped circular RNA. Cell Biomaterials.2026; article 100555. https://doi.org/10.1016/j.celbio.2026.100555 |
FL0445 is a biodegradable, multi-branched ionizable lipid featuring an ionizable amine-containing headgroup together with ester and carbonate linkages. When formulated with DOPE, cholesterol, and a PEG lipid, FL0445-LNP enabled efficient delivery of both linear mRNA and structurally constrained capped circular RNA (Cap-cirRNA). In the reported study, the optimized formulation produced substantially higher in vitro protein expression than benchmark LNPs based on MC3, SM-102, or ALC-0315 and demonstrated functional nucleic-acid delivery following intravenous, intramuscular, and subcutaneous administration in mice. The platform was also evaluated for mRNA vaccination, ASO-mediated gene silencing, pDNA delivery, and GLP-1-encoding Cap-cirRNA. FL0445-LNP induced comparatively low inflammatory cytokine responses and showed favorable single-dose tolerability in the tested mouse models, supporting its further evaluation as a versatile preclinical delivery lipid for mRNA, circular RNA, and other nucleic-acid modalities.
Specifications shown are product-page values, not batch test results.
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