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113-AA-C8C14
Datasheet
Product identity and specifications
| Item | Information |
|---|---|
| Product | 113-AA-C8C14 |
| Catalog number | DC60942 |
| CAS No. | Not assigned |
| Molecular formula | C61H117N5O8S2 |
| Molecular weight | 1112.768 |
| Purity specification | >95% by ELSD-HPLC |
Product description
Description & Application Spleen-tropic ionizable lipid for systemic mRNA delivery research 113-AA-C8C14 is a spleen-tropic ionizable lipid with inherent splenic organ selectivity. Its formulated LNPs drastically reduce off-target liver uptake and drive 57-fold higher mRNA expression in spleen versus benchmark LNPs. It preferentially delivers nucleic acids to splenic immune cells like macrophages and T lymphocytes, supporting in vivo CAR-T engineering and mRNA vaccine research with minimal accumulation in other visceral organs. Lead selection Top performer from a two-stage lipid screen Formulation context Four-component B-2 LNP formulation Organ tropism Spleen-selective delivery after i.v. dosing RNA cargo Luciferase mRNA and CD19-CAR mRNA RNA Delivery Spleen delivery Extrahepatic delivery In vivo CAR research Cationic and ionizable lipids Featured lipid products T-cell delivery
Formulation and performance
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Ordering
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