PRODUCT DATASHEET · DC60941
Antioxidant lipid AO12
Version 1.2949703f · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Antioxidant lipid AO12 |
| Synonyms | Antioxidant-lipid-AO12 |
| SMILES | Not available |
| Formula | C53H95NO7 |
| M.Wt | 858.34 |
| Purity | 98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Author, A. A., Author, B. B., & Author, C. C. (2026). Antioxidant lipid nanoparticles enhance mRNA stability for tissue regeneration and gene editing. Nature Communications, 17, Article 73512. doi.org |
AO12 is a novel antioxidant ionizable lipid derived from SM-102 skeleton with para-hydroxyphenyl propionic acid side chains. Integrated into LNPs, it efficiently scavenges diverse reactive oxygen species including ·OH and ONOO⁻, shielding encapsulated mRNA from oxidative degradation. It retains fine LNP formulation features and cellular uptake capacity of conventional lipids, boosting in vivo mRNA translation. Applied for regenerative mRNA therapy and CRISPR gene editing against fibrosis and inflammatory disorders.
Specifications shown are product-page values, not batch test results.
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