A2T2C9 (CP-LC-1465)
Version 1.3e36611f · 2026-09-13
| CAS No. | Not available |
| Chemical Name | A2T2C9 (CP-LC-1465) |
| Synonyms | CPLC1465， CP LC 1465 |
| SMILES | CCCCCCCCOC(=O)CCSCCC(CCCCC(=O)NC(CCSCCC(=O)OCC(CCCCCC)CCCCCCCC)C(=O)NCCN1C=CN=C1)SCCC(=O)OCCCCCCCC |
| Formula | C58H106O8N4S3 |
| M.Wt | 1,083.69 |
| Purity | 98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
A2T2C9 (CP-LC-1465) is an imidazole-based ionizable lipid with branched hydrophobic chains and β-propionate linkers, formulated in four-component LNPs for spleen-targeted mRNA delivery. It achieves >80% spleen selectivity with protein expression exceeding 1×10⁷ p/s in mice, driven by its negative zeta potential (-9.7 to -19 mV). Structural features including imidazole polar head and branched acrylate (C9) enhance splenic tropism, potentially through distinct protein corona interactions. Demonstrated low cytotoxicity (>75% viability in splenic cells) and biodegradability via pH-sensitive linkers enable efficient mRNA delivery without permanent charged additives, outperforming conventional anionic SORT systems in selectivity and therapeutic potential.
Specifications shown are product-page values, not batch test results.
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