A3T2C7 (CP-LC-1495)
Version 1.159609d6 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | A3T2C7 (CP-LC-1495) |
| Synonyms | A3T2-C7 |
| SMILES | CCCCCCCCOC(=O)CCSCCC(CCCCC(=O)NC(CCSCCC(=O)OCC(CC)CCCC)C(=O)NCCN1CCC1)SCCC(=O)OCCCCCCCC |
| Formula | C50H93O8N3S3 |
| M.Wt | 960.49 |
| Purity | 98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
A3T2C7 (CP-LC-1495) is a biodegradable ionizable lipid featuring three β-propionate linkers and an azetidine polar head, formulated in four-component LNPs. It demonstrates exceptional lung-targeted mRNA delivery with 97.1% selectivity and high protein expression (1.21×10⁸ p/s) in mice. Its slightly positive zeta potential (~3.5 mV) correlates with lung tropism, likely mediated by protein corona enrichment of vitronectin and prothrombin. The β-propionate structure enables pH-sensitive biodegradability for enhanced endosomal escape while maintaining low cytotoxicity (>90% cell viability). This lipid enables organ-specific mRNA delivery without permanently charged additives, outperforming conventional SORT strategies in selectivity and expression efficiency.
Specifications shown are product-page values, not batch test results.
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