DC60821 · Updated 27 October 2026

Lipid TOT-5

Product Datasheet

TOT-5 is a tri-oleoyl-Tris ionizable lipid investigated for spleen-directed mRNA delivery. Suzuki et al. showed that phospholipid composition influenced liver-versus-spleen expression and uptake by splenic B cells. The study includes reporter expression, model-antigen immune responses and comparative mouse tolerability data.

CAS No.	Not available
Chemical Name	Lipid TOT-5
Synonyms	Lipid TOT 5，TOT5
SMILES	CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COC(=O)CCCCCCC/C=C\CCCCCCCC)(COC(=O)CCCCCCC/C=C\CCCCCCCC)NC(=O)CCN1CCCCC1
Formula	C66H120N2O7
M.Wt	1053.693
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Suzuki Y, Yakuwa M, Sato M, et al. Splenic B cell-targeting lipid nanoparticles for safe and effective mRNA vaccine delivery. Journal of Controlled Release 382, 113687 (2025). DOI:10.1016/j.jconrel.2025.113687. Supporting information: Tables S4–S6, Figures S4–S15 and supplementary methods.

Research evidence

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Specifications are catalog specifications, not batch test results.