CL15F 9-5
Version 1.4b09c278 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | CL15F 9-5 |
| Synonyms | CL15F 9 5 |
| SMILES | CCCCCCCC(CCCCC)C(=O)OCCCCCCC(O)(CCCCCCOC(=O)C(CCCCC)CCCCCCC)CCCCOC(=O)C1CCN(C)CC1 |
| Formula | C56H107NO7 |
| M.Wt | 906.468 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Overcoming thermostability challenges in mRNA–lipid nanoparticle systems with piperidine-based ionizable lipids Kazuki Hashiba 1Yusuke Sato. Commun Biol. 2024 May 10;7:556. doi: 10.1038/s42003-024-06235-0 |
CL15F 9-5, a piperidine-based ionizable lipid, exhibits favorable properties for mRNA delivery in lipid nanoparticles (LNPs). Its apparent pKa ranges between 6.24–7.15, ideal for mRNA encapsulation and endosomal escape. LNPs formulated with CL15F 9-5 (50:38.5:10:1.5 molar ratio of ionizable lipid:cholesterol:DSPC:DMG-PEG2k) demonstrated high mRNA encapsulation efficiency (>90%) and maintained physicochemical stability (size, PDI, zeta potential) during storage at 4°C for 5 months . In vitro, CL15F 9-5 LNPs showed superior luciferase expression in HEK-293T cells compared to CL4F-based LNPs. In vivo, liver-targeted LNPs delivered hEPO mRNA effectively, with sustained serum hEPO levels post-storage. Intravenous administration of FLuc mRNA-loaded CL15F 9-5 LNPs yielded strong hepatic bioluminescence, confirming liver tropism. As a vaccine candidate, CL15F 9-5 induced robust antigen-specific cellular immunity in mice, with a 14-fold increase in IFN-γ spots compared to SM-102. Its enhanced stability is attributed to reduced aldehyde impurities, minimizing mRNA-lipid adduct formation.
Specifications shown are product-page values, not batch test results.
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