PRODUCT DATASHEET · DC60639
Acid-degradable Anionic Lipid (ADA)
Version 1.c6a022ad · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Acid-degradable Anionic Lipid (ADA) |
| Synonyms | Acid degradable Anionic Lipid |
| SMILES | [Li]OC(=O)C1=C(C(=O)NCCOC(OCCNC(=O)O[C@H]2CC[C@@]3(C)C(=CC[C@@H]4[C@@H]3CC[C@@]3(C)[C@H]4CC[C@@H]3[C@H](C)CCCC(C)C)C2)C2=CC=C(N3N=N3)C=C2)C=C(C(=O)O[Li])C(C(=O)O[Li])=C1 |
| Formula | C49H62Li3N5O 11 |
| M.Wt | 917.88 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Acid-degradable lipid nanoparticles enhance the delivery of mRNA-Sheng Zhao, Aijun Wang, Niren Murthy, Nat Nanotechnol 2024 Aug 23. - Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein Kai Chen, Hesong Han, Sheng Zhao, Bryant Xu, Boyan Yin, Atip Lawanprasert, Marena Trinidad, Benjamin W. Burgstone, Niren Murthy & Jennifer A. Doudna ---Nature Biotechnology (2024) |
ADA (Acid-Degradable Anionic Lipids) is revolutionizing mRNA delivery with its unique azido-acetal linker, enabling rapid hydrolysis in endosomes (pH ~6.0). This breakthrough technology ensures efficient endosomal escape, significantly enhancing mRNA delivery to target cells. ADA-LNPs excel in delivering mRNA to the spleen and liver, making them ideal for immune-related therapies.By degrading into biocompatible byproducts, ADA minimizes long-term tissue persistence and toxicity.ADA-LNPs outperform traditional LNPs, delivering mRNA more effectively to immune cells like macrophages and B cells.
Specifications shown are product-page values, not batch test results.
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