PRODUCT DATASHEET · DC60636
Acid-degradable Cationic Lipid (ADC)
Version 1.5303db68 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Acid-degradable Cationic Lipid (ADC) |
| Synonyms | Acid degradable Cationic Lipid |
| SMILES | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)NCCOC(OCC[N+](C)(C)C)C5=CC=C(N6N=N6)C=C5)CC[C@]4(C)[C@H]3CC[C@@]21C.CC1=CC=C(S(=O)(=O)[O-])C=C1 |
| Formula | C42H68N5O4.C7H7O3S |
| M.Wt | 878.23 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Acid-degradable lipid nanoparticles enhance the delivery of mRNA-Sheng Zhao, Aijun Wang, Niren Murthy, Nat Nanotechnol 2024 Aug 23. - Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein Kai Chen, Hesong Han, Sheng Zhao, Bryant Xu, Boyan Yin, Atip Lawanprasert, Marena Trinidad, Benjamin W. Burgstone, Niren Murthy & Jennifer A. Doudna ---Nature Biotechnology (2024) |
Acid-degradable Cationic Lipid (ADC) composed of cationic lipid is synthesized with the azido-acetal linker and used to generate RD-LNPs, which significantly improves the performance of LNP-mRNA complexes in vitro and in vivo.
Specifications shown are product-page values, not batch test results.
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