Lipid GVS-18-B6
Version 1.e93fc79b · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid GVS-18-B6 |
| Synonyms | Lipid GVS 18 B6, GVS-18-B6 |
| SMILES | CCCCC/C=C\CCCO[Si](CCCCN(C)C)(OCCC/C=C\CCCCC)OCCC/C=C\CCCCC |
| Formula | C36H71NO3Si |
| M.Wt | 594.05 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Holland R, Lam K, Jeng S, et al. Silicon Ether Ionizable Lipids Enable Potent mRNA Lipid Nanoparticles with Rapid Tissue Clearance. ACS Nano. 2024;18:10374-10387. |
GVS-18-B6 is a biodegradable silicon-ether ionizable lipid reported for liver-directed mRNA delivery. The literature-verified structure contains a dimethylamino headgroup connected through a four-carbon linker to a silicon center bearing three cis-4-decenyl ether chains. In the cited study, GVS-18-B6 LNPs showed high mRNA encapsulation, an apparent LNP pKa of 6.15, preferential hepatic expression after intravenous administration, rapid tissue clearance, and favorable tolerability in the reported mouse and nonhuman-primate experiments. All formulation and performance values shown below are literature-reported study results, not specifications or guaranteed performance of the supplied lipid.
Specifications shown are product-page values, not batch test results.
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