DC60564 · Updated 27 October 2026

Lipid GVS-18-B6

Product Datasheet

GVS-18-B6 is a silicon-ether ionizable lipid evaluated for liver-directed mRNA delivery. The 2024 ACS Nano study reports hepatic protein expression, rapid parent-lipid clearance, cellular trafficking observations, mouse tolerability and repeat administration in cynomolgus monkeys. These findings apply to the specified research formulations.

CAS No.	Not available
Chemical Name	Lipid GVS-18-B6
Synonyms	Lipid GVS 18 B6, GVS-18-B6
SMILES	CCCCC/C=C\CCCO[Si](CCCCN(C)C)(OCCC/C=C\CCCCC)OCCC/C=C\CCCCC
Formula	C36H71NO3Si
M.Wt	594.05
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Holland R, Lam K, Jeng S, et al. Silicon Ether Ionizable Lipids Enable Potent mRNA Lipid Nanoparticles with Rapid Tissue Clearance. ACS Nano. 2024;18:10374–10387. DOI: 10.1021/acsnano.3c09028. Table 1; Figures 2–7; Materials and Methods. Supporting Information, nn3c09028_si_001.pdf. Table S2 (mPEG-DMA and measured composition); Figure S3 (hemolysis); Figure S4 (protein corona).

Research evidence

Read detailed Formulation & Performance

Specifications are catalog specifications, not batch test results.