DC Chemicals

DC60537 · Updated 28 October 2026

C18 NC-TNP

Instructions for Use

Before use

Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.

For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.

Stock-solution planning

Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].

Mass10 mM20 mM
10 mg1.2734 mL0.6367 mL
25 mg3.1836 mL1.5918 mL
50 mg6.3672 mL3.1836 mL
100 mg12.7344 mL6.3672 mL

Literature formulation reference

ComponentDC Chemicals productMolecular weightMolar ratioMass at 1 µmol total lipid (mg)
C18 NC-TNPDC60537785.274600.471164
CholesterolDCD-041386.65400.154660

Noncationic thiourea lipid/cholesterol = 60:40 mol%. Source: main Methods, preparation of NC-TNP. The carrier does not use the four-component SM-102 comparator composition. N/P is not assigned to this hydrogen-bond-based noncationic formulation.

Read the complete study conditions, biological results, tolerability and figures →

References

  1. Wang C, et al. Biomimetic noncationic lipid nanoparticles for mRNA delivery. PNAS 120, e2311276120 (2023). DOI: 10.1073/pnas.2311276120.
  2. Full text and SI Appendix: main Figs. 1–5; supplementary immune-memory experiments.