C18 NC-TNP
Version 1.4d439887 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | C18 NC-TNP |
| Synonyms | C18 NC TNP , C18NCTNP |
| SMILES | CCCCCCCCCCCCCCCCCCOC(=O)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)NC(NCC(O)CO)=S |
| Formula | C45H88O6N2S |
| M.Wt | 784.64 |
| Purity | 98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Biomimetic noncationic lipid nanoparticles for mRNA delivery (Wang et al.)-Proc Natl Acad Sci U S A . 2023 Dec 19;120(51) |
C18 NC-TNP is a novel noncationic thiourea lipid without positively charged groups. It binds nucleic acids via hydrogen bonds instead of electrostatic attraction, avoiding cation-triggered systemic inflammation. Formulated into nanoparticles, it efficiently encapsulates mRNA, siRNA and plasmids, shows excellent serum tolerance and long-term liquid/lyophilized storage stability. It enters cells mainly through macropinocytosis, escapes endosomes intact to reduce nucleic acid degradation. In vivo, it targets spleen preferentially, induces robust long-lasting Th1-type cellular and humoral immunity with minimal organ toxicity, superior to SM102 LNPs for mRNA cancer vaccine delivery.
Specifications shown are product-page values, not batch test results.
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