DC Chemicals

DC60510 · Updated 28 October 2026

Iso-A11B5C1

Product Datasheet

Iso-A11B5C1 is an ionizable lipid investigated for muscle-selective mRNA delivery after intramuscular administration. In the cited mouse study, its LNP formulation retained local expression while limiting detectable liver and spleen reporter expression relative to the SM-102 comparator.

CAS No.Not available
Chemical NameIso-A11B5C1
SynonymsIsoA11B5C1, Iso A11B5C1, iso-A11B5C1, H3
SMILESCCCCCCCC/C=C\CCCCCCCCNC(=O)C(CCCCCOC(=O)CCC(C)CCCCC)NCCN1CCCC1
FormulaC41H79N3O3
M.Wt662.10
Purity>95% by ELSD-HPLC
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
Publication
  1. Chen J, Xu Y, Zhou M, et al. Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects. PNAS 120, e2309472120 (2023). DOI: 10.1073/pnas.2309472120.
  2. Full text and Supporting Information, Table S2 and Figures S4/S8.

Research evidence

Read detailed Formulation & Performance

Specifications are catalog specifications, not batch test results.