PRODUCT DATASHEET · DC60508
4A3-SCC-10
Product Datasheet
Version 1.a98a10a4 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | 4A3-SCC-10 |
| Synonyms | 4A3SCC10， 4A3 SCC 10 |
| SMILES | O=C(OCCSSCCOC(C(C)CSCCCCCCCCCC)=O)CCN(CCCN(C)CCCN(CCC(OCCSSCCOC(C(C)CSCCCCCCCCCC)=O)=O)CCC(OCCSSCCOC(C(C)CSCCCCCCCCCC)=O)=O)CCC(OCCSSCCOC(C(C)CSCCCCCCCCCC)=O)=O |
| Formula | C91H171N3O16S12 |
| M.Wt | 1,948.18 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Chen et al. Modular Design of Biodegradable Ionizable Lipids for Improved mRNA Delivery and Precise Cancer Metastasis Delineation In Vivo. JACS (2023). DOI: 10.1021/jacs.3c09143. Supporting Information pp.18-21, Schemes S6/S7 and Fig.S31. |
4A3-SCC-10 is a disulfide bond-containing biodegradable ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing 4A3-SCC-10 and encapsulating a Cy5-RNA reporter have improved endosomal escape ability over Cy5-RNA-encapsulated LNPs containing 4A3-SC-10, which does not contain disulfide bonds, in HeLa cells. Intravenous administration of LNPs containing 4A3-SCC-10 and encapsulating an mRNA luciferase reporter selectively accumulate in mouse liver.
Specifications shown are product-page values, not batch test results.
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