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ALC-0366

Version 1.596068c7 · 2026-09-13

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CAS No.Not available
Chemical NameALC-0366
SynonymsALC0366, ALC 0366,ALC366, ALC 366, ALC-366
SMILESOCCCN(CCCCCCCCCOC(C(CCCC)CCCCCC)=O)CCCCCCCCCOC(C(CCCC)CCCCCC)=O
FormulaC45H89NO5
M.Wt724.2
PurityELSD-HPLC>95%
StorageOriginal product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationPreclinical efficacy and pharmacokinetics of an RNA-encoded T cell-engaging bispecific antibody targeting human claudin 6-Sci Transl Med . 2024 May 22;16(748):eadl2720. doi: 10.1126/scitranslmed.adl2720.

ALC 0366 is an ionizable cationic lipid (pKa = 6.25) from Biontech,which is derived from ALC-0315. ALC0366 has been used as a key component of LNP to deliver BNT142, a lipid nanoparticle (LNP)-formulated RNA (RNA-LNP) encoding a T cell-engaging bispecific antibody that monovalently binds the T cell marker CD3 and bivalently binds claudin 6 (CLDN6), an oncofetal antigen that is absent from normal adult tissue but expressed on various solid tumors.

Specifications shown are product-page values, not batch test results.

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