PRODUCT DATASHEET · DC60475
CL4F8-6
Version 1.2342f49c · 2026-09-13
| CAS No. | Not available |
| Chemical Name | CL4F8-6 |
| Synonyms | CL4F8 6， CL4F86, INNYA-23062004 |
| SMILES | C(O)(CCCCCCOC(=O)C(CCCCCC)CCCCCC)(CCCCCCOC(=O)C(CCCCCC)CCCCCC)CCCCN(CCC)CCC |
| Formula | C51H101NO5 |
| M.Wt | 808.35 |
| Purity | >95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | [1]. Kazuki Hashiba, et al. Branching Ionizable Lipids Can Enhance the Stability, Fusogenicity, and Functional Delivery of mRNA. Small Science. 09 November 2022. |
CL4F8-6 is an ionizable cationic lipid (pKa = 6.14) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).1 LNPs containing CL4F8-6 and encapsulating an mRNA reporter accumulate specifically in the mouse liver after intravenous administration. LNPs containing CL4F8-6 and encapsulating mRNA encoding the Cas9 nuclease (mCas9) and single-guide RNA (sgRNA) targeting Ttr (sgTtr), the gene encoding transthyretin, have been used to induce CRISPR-mediated gene knockdown in mice resulting in a reduction of serum levels of TTR.
Specifications shown are product-page values, not batch test results.
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