DC49882 · Updated 28 October 2026
cKK-E12
Instructions for Use
Before use
Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.
Stock-solution planning
Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].
| Mass | 10 mM | 20 mM |
|---|---|---|
| 10 mg | 1.0064 mL | 0.5032 mL |
| 25 mg | 2.5161 mL | 1.2580 mL |
| 50 mg | 5.0321 mL | 2.5161 mL |
| 100 mg | 10.0642 mL | 5.0321 mL |
Literature formulation reference
| Component | DC Chemicals product | Molecular weight | Molar ratio | Mass at 1 µmol total lipid (mg) |
|---|---|---|---|---|
| cKK-E12 | DC49882 | 993.62 | Not assigned | Not calculable from disclosed data |
| DSPC | DC57005 | 790.15 | Not assigned | Not calculable from disclosed data |
| Cholesterol | DCD-041 | 386.65 | Not assigned | Not calculable from disclosed data |
| PEG-lipid (identity unassigned) | Not uniquely mapped | Not established | Not assigned | Not calculable from disclosed data |
Main text identifies cKK-E12, DSPC, cholesterol and a PEG-lipid. The complete 2014 SI was not retrieved, so molar ratios, PEG identity/MW, N/P and lipid:RNA mass ratio are not assigned. A familiar 50:10:38.5:1.5 recipe is not assumed to be the verified original formulation.
Read the complete study conditions, biological results, tolerability and figures →