DC Chemicals

DC49882 · Updated 28 October 2026

cKK-E12

Product Datasheet

cKK-E12 is an ionizable lipopeptide lipid investigated for hepatocyte-selective siRNA delivery. Published studies report potent factor VII silencing in rodents and greater than 95% liver TTR mRNA silencing in cynomolgus monkeys at 0.3 mg/kg siRNA.

CAS No.1432494-65-9
Chemical NameCKK-E12
Synonyms2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]-;CKKE12， CKK E12
SMILESN1C(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C(=O)NC(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C1=O
FormulaC60H120N4O6
M.Wt993.62
Purity>95% by ELSD-HPLC
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
Publication
  1. Dong Y, Love KT, Dorkin JR et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. PNAS 111, 3955–3960 (2014). DOI: 10.1073/pnas.1322937111.
  2. Correction: additional funding acknowledgments. PNAS 111, 5753 (2014). DOI: 10.1073/pnas.1404711111.

Research evidence

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Specifications are catalog specifications, not batch test results.