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DMHAPC-Chol

Version 1.e685ba01 · 2026-09-13

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CAS No.Not available
Chemical NameDMHAPC-Chol
SynonymsDMHAPC Chol, Dimethyl Hydroxyethyl Aminopropane Carbamoyl Cholesterol Iodide
SMILESC[C@H](CCCC(C)C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(NCCC[N+](C)(C)CCO)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
FormulaC35H63N2O3
M.Wt559.9
Purity>98%
StorageOriginal product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationNot available

DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells. DMHAPC-Chol, as part of a lipoplex with DOPE, has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to deliver VEGF siRNA into A431 and MDA-MB-231 cells, which secrete VEGF.

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