SM-86(Lipid 5)
Version 1.3b33502b · 2026-09-13
| CAS No. | Not available |
| Chemical Name | SM-86(Lipid 5) |
| Synonyms | LIPID5 LIPID-5, SM86, SM 86 |
| SMILES | O=C(CCCCCCCN(CCCCCCCC(=O)OCCCCCCCCC)CCO)OC(CCCCCCCC)CCCCCCCC |
| Formula | C44H87NO5 |
| M.Wt | 710.165 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria--Published: 07 May 2024-Rena Baek, Patrick Finn & Paolo G. V. Martini |
SM86 is a cationic, ionizable lipid developed by Moderna as a core component of its lipid nanoparticle (LNP) platform for mRNA therapeutic delivery.SM-086 is structurally optimized and analogous to SM-102 (used in Moderna’s COVID-19 vaccines), with modifications aimed at enhancing mRNA delivery efficiency and safety.SM-86 serves as the primary cationic lipid in three investigational mRNA therapies targeting rare metabolic disorders:mRNA-3927: Restores propionyl-CoA carboxylase activity in propionic acidemia (PA). mRNA-3705: Delivers methylmalonyl-CoA mutase mRNA for methylmalonic acidemia (MMA). mRNA-3210: Provides phenylalanine hydroxylase mRNA to treat phenylketonuria (PKU).
Specifications shown are product-page values, not batch test results.
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