DC31024 · Updated 27 October 2026

SM-86 (Lipid 5)

Product Datasheet

SM-86 is an ionizable lipid used in the SM-86/OL-56 nanoparticle platform studied for hepatic delivery of enzyme-encoding mRNA. Baek et al. evaluated three distinct formulations: mRNA-3927 for propionic acidemia, mRNA-3705 for methylmalonic acidemia and mRNA-3210 for phenylketonuria. The study connects liver protein expression with enzyme activity and disease biomarkers in mouse models. These results describe complete mRNA-LNP products; they do not establish the potency or safety of unformulated SM-86.

CAS No.	2089251-33-0
Chemical Name	SM-86 (Lipid 5)
Synonyms	SM-86 (Lipid 5); LIPID5; LIPID-5; SM86; SM 86
SMILES	O=C(CCCCCCCN(CCCCCCCC(=O)OCCCCCCCCC)CCO)OC(CCCCCCCC)CCCCCCCC
Formula	C44H87NO5
M.Wt	710.165
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Baek R, et al. Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria. Nature Communications 15, 3804 (2024). Supplementary Information: formulation distinctions and Tables 1–10. Source Data accompanying the article.

Research evidence

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Specifications are catalog specifications, not batch test results.