Literature-reported formulation composition
Component: DLin-DMA | mol%: 50 | Role: Ionizable lipid
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DLinDMA
Literature records
Search the tables and observations reproduced from the product literature guide. Rows may represent measurements, recipes or experimental context; they are not all independent experiments.
Literature-reported formulation composition
Component: DSPC | mol%: 10 | Role: Helper phospholipid
Literature-reported formulation composition
Component: Cholesterol | mol%: 38.5 | Role: Sterol
Literature-reported formulation composition
Component: DMG-PEG2000 | mol%: 1.5 | Role: PEG lipid
Literature-reported formulation composition
Component: Reported total | mol%: 100 | Role: Source values retained
Table 3
Parameter: DLS number diameter | DLin-DMA result: 62.79 and 69.72 nm | Source: Source Data Fig.3b
Table 3
Parameter: PDI | DLin-DMA result: 0.246 and 0.249 | Source: Source Data Fig.3b
Table 3
Parameter: Encapsulation efficiency | DLin-DMA result: 72.95% and 74.72% | Source: Source Data Fig.3d
Table 3
Parameter: TNS apparent LNP pKa | DLin-DMA result: 6.66 | Source: Source Data Fig.1d
Table 3
Parameter: Zeta-potential pKa / pI | DLin-DMA result: 6.15 / 6.34 | Source: Source Data Fig.1d
Table 3
Parameter: Water-soluble analogue pKa | DLin-DMA result: 8.93 | Source: Source Data Fig. 1d
Reported observation
Calculated from published source data In vitro FLuc reporter signal 251-335 RLU at 25 ng; 1543-1920 RLU at 200 ng HEK293, 24 h after transfection, n=3 · Common five-lipid comparison; authors reported KC2 > MC3 > DLin > DODMA > DODAP under these conditions Range calculated from the three published source-data replicates at each selected dose; intermediate 50 and 100 ng data remain in the source workbook. Main p.5 Fig.3a; Supplementary Data 3, 'Figure 3a'!B3:N7; DLin row B5:N5
Reported observation
Calculated from published source data Intramuscular FLuc expression 61.59-68.35 million photons/s at 4 h; 7.844-15.64 million photons/s at 24 h 5 micrograms FLuc mRNA-LNP/mouse, IM; female BALB/c mice · 4 and 24 h · Five ionizable-lipid formulations at the same composition and N/P Ranges calculated from published source-data values. Main p.7 Fig.4c; Supplementary Data 4, 'Figure 4c'!B5:H5
Reported observation
Calculated from published source data Intravenous liver FLuc expression 401.8 and 594.7 million photons/s at 4 h; 35.79-190.3 million photons/s at 24 h 5 micrograms FLuc mRNA-LNP/mouse, IV; female BALB/c mice · 4 and 24 h · Five ionizable-lipid formulations at the same composition and N/P Published source-data values; the 4 h sheet contains two DLin values, so no missing third replicate was invented. Main p.7 Fig.4d; Supplementary Data 4, 'Figure 4d'!B5:H5