All products / DC70750
Rv1625c agonist V-59
Pack sizes and prices
| Pack size | Price |
|---|---|
| 100 mg | $850 USDRequest a quote / confirm availability → |
| 250 mg | $1,300 USDRequest a quote / confirm availability → |
| 1 g | $2,600 USDRequest a quote / confirm availability → |
Confirm stock, lead time, shipping and final quotation with our team.
Product overview
Rv1625c agonist V-59 (V-59) is a specific small molecule agonist of the Mtb adenylyl cyclase Rv1625c, inhibits Mtb growth in macrophages (EC50=0.3 uM) in an Rv1625c-dependent mechanism.V-59 inhibits Mtb growth in cholesterol media (EC50 0.70 uM), but not in media containing the two-carbon fatty acid acetate, or in standard rich growth media.V-59 stimulates Rv1625c to produce cAMP, which is necessary for V-59 to inhibit Mtb growth.Chemically activating Rv1625c via V-59 preferentially inhibits cholesterol utilization in WT Mtb, rather than equally inhibiting all lipid utilization by the bacterium.
For research use only. Results depend on experimental conditions and do not constitute a performance guarantee.
Identity and specifications
| Catalog number | DC70750 |
|---|---|
| Product name | Rv1625c agonist V-59 |
| CAS | 958588-17-5 |
| Molecular formula | C17H18FN7O2 |
| Molecular weight | 371.376 |
| Purity | >98% |
| SMILES | Cc1nonc1CC(=O)N1CCC(n2nnc(-c3ccc(F)cc3)n2)CC1 |
Source-listed specifications; the batch COA applies.
Source and product documents
The supplier source is linked below. Contact us for COA, SDS and batch-specific documents.
DC Chemicals — Rv1625c agonist V-59 (DC70750)