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N-piperidine Ibrutinib hydrochloride
CAT. NO. DC40447

N-piperidine Ibrutinib hydrochloride

Pack sizes and prices

Pack sizePrice
100mg$700 USDRequest a quote / confirm availability →
250mg$1,200 USDRequest a quote / confirm availability →
1g$2,400 USDRequest a quote / confirm availability →

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Product overview

N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.

For research use only. Results depend on experimental conditions and do not constitute a performance guarantee.

Identity and specifications

Catalog numberDC40447
Product nameN-piperidine Ibrutinib hydrochloride
CAS2231747-18-3
Molecular formulaC22H23ClN6O
Molecular weight422.9106
Purity>98%
SMILESCl.Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCNCC1

Source-listed specifications; the batch COA applies.

Source and product documents

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DC Chemicals — N-piperidine Ibrutinib hydrochloride (DC40447)

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