DCL0022 · Research use only
FS01 · Datasheet
FS01 is a squaramide-containing ionizable lipid investigated for local mRNA delivery to joints. In a head-to-head mouse intra-articular screen, FS01 lipid nanoparticles produced higher luciferase expression than formulations containing Lipid 5, SM-102 or LP01 under the tested conditions. FS01 was subsequently used to deliver IL-1Ra mRNA and a C-terminal truncated ANGPTL3 mRNA (ANL3), individually or in combination. The combined formulation was evaluated in mouse rheumatoid arthritis and osteoarthritis models for suppression of inflammation and preservation of cartilage. These findings support research into intra-articular mRNA delivery; the therapeutic results concern the complete mRNA-loaded formulation.
| Parameter | Specification |
|---|---|
| CAS No. | Not available |
| Chemical Name | FS01 |
| Synonyms | FS-01; FS 01 |
| SMILES | CCCCCCCCC(CCCCCCCC)OC(=O)CCCCCCCN(CCCCCCCC(=O)OCCc1ccccc1CCCC)CCCNc1c(NC)c(=O)c1=O |
| Formula | C53H91N3O6 |
| M.Wt | 866.33 |
| Purity | >95% by ELSD-HPLC |
| Storage | Refer to the supplied batch label and documentation. |
| Shipping condition | Contact us for current shipping conditions. |
| Publication | Wang et al., Molecular Therapy (2026) |
Literature overview
Intra-articular delivery, mouse arthritis and cartilage research. See the linked Formulation & Performance page for cargo-specific measurements and source limitations.
References
- Wang G, et al. A Combinatorial mRNA Therapy for Treating Rheumatoid Arthritis and Osteoarthritis by Inhibiting Inflammation and Preventing Cartilage Degeneration. Molecular Therapy (2026), journal pre-proof. DOI: 10.1016/j.ymthe.2026.10.021. Main source for the study tables and figures on this page.
- Guo K, et al. A novel ionizable lipid with comprehensive improvements in transfection potency, immune profile and safety of lipid nanoparticle. Journal of Controlled Release 386, 114126 (2025). DOI: 10.1016/j.jconrel.2025.114126. Earlier FS01 publication cited by Wang et al.; not used to fill missing N/P values.
- CN120208802A, published 27 June 2025. FS01 structure: paragraphs 0116–0119, PDF page 14; formulation component order: paragraph 0121. Chemical preparation details are not reproduced here.