Website: www.dcchemicals.com
Email: info@dcchemicals.com · Phone: +86-21-58447131
Room 610, Building 15, Jinxiang Rd 201, Shanghai, China
Datasheet — U-502
DCL0014 · Updated 16 October 2026
Description:
U-502 is a Janus dendritic ionizable lipid with two tertiary amines, two hydroxyl groups and six C8 alkyl tails attached through ether-containing dendrons and ester linkers. In a 16-lipid study, U-502 and U-503 were the leading intravenous mRNA-expression candidates, with modestly higher luciferase signals than ALC-0315 in BALB/c mice at 0.5 mg/kg mRNA and a 3-hour readout. The U-502 formulation had a reported size of 108 nm, PDI of 0.125, apparent LNP pKa of 6.36 and mRNA encapsulation efficiency of 91.83%. U-502 also underwent cell transfection, lysosomal colocalization and representative tissue-histology studies. It supports preclinical research into liver-dominant systemic mRNA delivery and headgroup–tail structure–activity relationships.
Chemical Information
| Parameter | Value |
|---|---|
| Catalog number | DCL0014 |
| Product name | U-502 |
| Aliases | U502; U 502; Janus lipid U-502 |
| Molecular formula | C77H154N2O12 |
| Molecular weight | 1300.08 g/mol |
| SMILES | CCCCCCCCOCC(COCCCCCCCC)(COCCCCCCCC)COC(=O)CCCCCN(CCCCCC(=O)OCC(COCCCCCCCC)(COCCCCCCCC)COCCCCCCCC)CCCN(CCO)CCO |
| Purity / availability | >95% by ELSD-HPLC |
| CAS No. | Not available |
| Form | Neutral parent; no counterion or solvate depicted |
| Storage | Unopened pure lipid: −20 °C, up to 1 year. Follow the batch expiry / retest date. |
Handling:
Store the unopened product at −20 °C, protected from light and moisture, with the vial tightly sealed. The standard storage period is 1 year; follow the expiry or retest date on the supplied batch documentation. Allow the closed vial to reach room temperature before opening to avoid condensation.
We ship the pure lipid with ice packs, without ethanol. Prepare an ethanol stock solution when required. Gentle warming and brief sonication may assist dissolution; confirm complete dissolution at the intended concentration.
Prepare and use solutions on the same day wherever possible. If advance preparation is required, use a validated storage procedure and tightly sealed aliquots. A general solution shelf life is not assigned.
For small amounts of oily or viscous lipid, dissolve the entire pack and take volumetric aliquots. For example, dissolve 25 mg and adjust to a final volume of 1 mL to obtain 25 mg/mL; a 100 µL aliquot contains 2.5 mg.
References:
Liu C, Jiang Y, Xue W, Liu J, Wang Z, Li X. Janus dendritic ionizable lipids with fine designed headgroup and tails to improve mRNA delivery efficiency. Bioorganic & Medicinal Chemistry. 2025;120:118080. doi:10.1016/j.bmc.2025.118080. Main article: 8 pages. Supporting Information: synthesis, Figs. S1–S50 and Table S1.