iL-19 — Product Datasheet
Description
iL-19 is an aminoethoxy-functionalized ionizable lipid with a triamine scaffold, two ester linkages and four doubly branched hydrophobic tails. It was identified as the overall lead for circular RNA delivery in a 2026 JACS study. With circRNA encoding firefly luciferase, iL-19 LNPs produced approximately 28-fold higher expression than the SM-102 benchmark in C2C12 cells and approximately 2.5-fold higher expression after intramuscular administration in BALB/c mice under the reported conditions. The reported circRNA formulation uses iL-19, DSPC, cholesterol and DMG-PEG2000 at 50:10:38.5:1.5 mol%. It supports preclinical investigation of circular RNA delivery to muscle; comprehensive safety and immunogenicity evaluation remains outstanding.
Specifications
| Parameter | Value |
|---|---|
| Catalog number | DCL0013 |
| Product name | iL-19 |
| Aliases | iL19; iL 19; IL-19; IL 19; iL-19 lipid |
| Molecular formula | C62H125N3O8 |
| Molecular weight | 1040.70 g/mol |
| SMILES | CC(C)CCCC(C)CCN(CCOCCOC(=O)CCCCN(CCCCC(=O)OCCOCCN(CCC(C)CCCC(C)C)CCC(C)CCCC(C)C)CCOCCO)CCC(C)CCCC(C)C |
| CAS number | Not reported |
| Purity / availability | >95% by ELSD-HPLC |
| Salt / stereochemistry | Neutral structure; no counterion depicted; four tail stereocenters unassigned |
| Storage | Follow batch-specific handling and storage documentation |
| Categories | Cationic/Ionizable Lipids; Ionizable Lipids for circRNA Delivery; Ionizable Lipids for Muscle Delivery |
Formulation & handling
Reported composition: iL-19 / DSPC / cholesterol / DMG-PEG2000 = 50 / 10 / 38.5 / 1.5 mol%. Ethanol stock preparation and citrate-buffer mixing are detailed in the Formulation guide. No commercial batch purity, expiry date or validated neat-lipid storage lifetime is inferred from the paper.
Reference
Cook A, Yadav PK, Helmy EW, Vlasova K, Chang HY, Wender PA. Circular RNA Delivery In Vitro and In Vivo Using Doubly Branched Aminoethoxy-Functionalized Ionizable Lipid Nanoparticles. Journal of the American Chemical Society (2026). DOI: 10.1021/jacs.6c14175. Main article (9 PDF pages) and Supporting Information (85 pages). Volume and final pagination are not assigned in the supplied version.
For research use only. Not for human or veterinary use. · sales@dcchemicals.com