PRODUCT DATASHEET · DC68023
Lipid 1A7B13
Version 1.656af901 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid 1A7B13 |
| Synonyms | Lipid 1A7B13 |
| SMILES | CCCCCCCCCCCC[N+](C)(CCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC)CCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC |
| Formula | C65H130O4N+ |
| M.Wt | 989.76 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Zeru Tian, Xu Wang, Sumanta Chatterjee, et al. Tripod-like lung-targeting (LuT) lipids for highly efficient and selective LNPs for gene delivery and editing. Nature Biomedical Engineering, 2026. doi: 10.1038/s41551-026-01615-9 |
1A7B13 is a top-performing "tripod-like" lung-targeting (LuT) lipid. It forms lipid nanoparticles (LNPs) that, after intravenous injection, deliver genetic medicines (like mRNA and CRISPR-Cas9) to the lungs with over 90% selectivity, particularly favoring epithelial cells. Compared to the benchmark DOTAP LNPs, 1A7B13 LNPs achieve a 25.5-fold increase in mRNA delivery and a 9.2-fold improvement in gene-editing efficiency within the lungs. Its therapeutic potential was demonstrated by successfully delivering IL-10 mRNA to treat acute lung injury in mice.
Specifications shown are product-page values, not batch test results.
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