DC67546 · Updated 27 October 2026

ALC-0307

Instructions for Use

Before use

Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.

For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.

Stock-solution planning

Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].

Mass	10 mM	20 mM
10 mg	1.1581 mL	0.5790 mL
25 mg	2.8952 mL	1.4476 mL
50 mg	5.7904 mL	2.8952 mL
100 mg	11.5808 mL	5.7904 mL

Literature formulation reference

Component	DC Chemicals product	Molecular weight	Molar ratio	Mass at 1 µmol total lipid (mg)
ALC-0307	DC67546	863.5	50	Not calculable from disclosed data
Phosphatidylcholine (specific species not resolved)	Not uniquely mapped	Not established	10	Not calculable from disclosed data
Cholesterol	DCD-041	386.65	38.5	Not calculable from disclosed data
PEG lipid (specific identity not resolved)	Not uniquely mapped	Not established	1.5	Not calculable from disclosed data

Tombácz 2021 core ratio: 50:10:38.5:1.5 mol/mol. RNA:total lipid approximately 0.04:1 by mass, equivalent to approximately 1:25. CD4-targeted particles also have antibody functionalization; this core ratio is not a complete conjugated-particle recipe. Do not substitute DSPC, ALC-0159 or DMG-PEG2000 for the generic components without confirming identity. These are not verified k-abe clinical ratios.

Read the complete study conditions, biological results, tolerability and figures →

ALC-0307

Before use

Stock-solution planning

Literature formulation reference

References