DC Chemicals

DC67515 · Updated 27 October 2026

CICL-207

Instructions for Use

Before use

Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.

For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.

Stock-solution planning

Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].

Mass10 mM20 mM
10 mg0.9752 mL0.4876 mL
25 mg2.4380 mL1.2190 mL
50 mg4.8761 mL2.4380 mL
100 mg9.7521 mL4.8761 mL

Literature formulation reference

ComponentDC Chemicals productMolecular weightMolar ratioMass at 1 µmol total lipid (mg)
CICL-207DC675151025.416Not assignedNot calculable from disclosed data
DSPCDC57005790.15Not assignedNot calculable from disclosed data
CholesterolDCD-041386.65Not assignedNot calculable from disclosed data
DSG-PEG2000Not uniquely mappedNot establishedNot assignedNot calculable from disclosed data
DSPE-PEG2000-maleimideNot uniquely mappedNot establishedNot assignedNot calculable from disclosed data

The patent describes F50 as a five-lipid system with a targeting ligand in the immune-cell studies. DSG-PEG2000 is a distinct ingredient from DMG-PEG2000. Ingredient names are provided for source identification; antibody-bearing and undecorated particles must be distinguished when interpreting biological results.

Read the complete study conditions, biological results, tolerability and figures →

References

  1. Karmali PP, Tanis S, Bao Y. Constrained Ionizable Cationic Lipids and Lipid Nanoparticles. US20250127728A1, published April 24, 2025. Example 17; Examples 66 and 69–72; Tables 9 and 13; Figures 2 and 7–12.