Literature-reported formulation composition
Component: Lipid M / Moderna Lipid 26 | mol%: 50 | Role: Ionizable lipid
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Moderna Lipid 26（Lipid M）
Literature records
Search the tables and observations reproduced from the product literature guide. Rows may represent measurements, recipes or experimental context; they are not all independent experiments.
Literature-reported formulation composition
Component: DSPC | mol%: 10 | Role: Helper phospholipid
Literature-reported formulation composition
Component: Cholesterol | mol%: 38.5 | Role: Sterol
Literature-reported formulation composition
Component: PEG lipid | mol%: 1.5 | Role: PEG lipid
Literature-reported formulation composition
Component: Reported total | mol%: 100 | Role: Source values retained
Reported observation
Literature-reported Apparent pKa 6.75 Lipid M structure panel Main article Fig. 3A, journal p. 4
Reported observation
Literature-reported NHP immunogenicity H10N8 ELISA and HAI titers for Lipid M were not statistically different from MC3 in the reported group-level comparisons. 5 mg modified H10N8 mRNA IM per dose; n=3 cynomolgus monkeys/group; days 0, 21, 42 Main article Fig. 4A-B and caption, journal pp. 5-6
Reported observation
Literature-reported NHP antibody expression Lipid M showed more expression over time than MC3 in the study's comparison (p=0.05). IM modified mRNA encoding antibody heavy/light chains Main article p. 4 and Fig. 4C caption, journal pp. 4-5
Reported observation
Literature-reported Rat local pathology Average scores for Lipid M at 0.01 mg were muscle fiber necrosis 2.0, muscle mixed-cell inflammation 2.0, muscle degenerate neutrophils 1.3, skin mixed-cell inflammation 1.7, and skin degenerate neutrophils 0; at 0.1 mg: 1.7, 2.7, 2.0, 2.0, and 0, respectively. Zika prM-E mRNA IM; n=3/group; 48 h; 0–4 pathology scale Main article Table 1, journal p. 6
Reported observation
Literature-reported Clearance Lead-lipid levels declined faster than MC3 in muscle, spleen, and liver after IM administration; Lipid M is one of the five lead lipids shown in Fig. 3B-D. Luciferase mRNA LNPs in CD-1 mice; n=3/time point; up to 48 h Main article Fig. 3B-D and journal p. 3