DC Chemicals

DC60855 · Updated 28 October 2026

4A3-SC7

Product Datasheet

4A3-SC7 is an ionizable lipid studied in organ-selective RNA delivery. Five-component formulations combine it with a SORT lipid to alter tissue delivery. Published evidence includes liver formulation optimization, pulmonary reporter delivery with DORI-containing LNPs, and multi-organ base-editing research.

CAS No.1857340-77-2
Chemical Name4A3-SC7​​
Synonyms4A3SC7​​， 4A3 SC7​​
SMILESO=C(CCN(CCCN(CCCN(CCC(OCCOC(C(CSCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCC)C)=O)=O)C)CCC(OCCOC(C(CSCCCCCCC)C)=O)=O)OCCOC(C(CSCCCCCCC)C)=O
FormulaC71H131N3O16S4
M.Wt1,411.07
Purity>95% by ELSD-HPLC
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
Publication
  1. Kim M, Song ES, Chen JC et al. Dual SORT LNPs for multi-organ base editing. Nature Biotechnology 44, 578–586 (2026); online 2 June 2025. DOI: 10.1038/s41587-025-02675-z.
  2. Supplementary Information: Figs. 1, 11–14; Tables 1–3 and additional methods.

Research evidence

Read detailed Formulation & Performance

Specifications are catalog specifications, not batch test results.