PRODUCT DATASHEET · DC60489
LIPID 331
Biodegradable cyclic ionizable lipid
Version 1 · 2026-09-20
| Chemical name | di((9Z,12Z)-octadeca-9,12-dien-1-yl) 4,4'-(2-(tert-butoxycarbonyl)-1-(2-(2-ethylpiperidin-1-yl)ethyl)-2,5-dihydro-1H-imidazole-5,5-diyl)dibutyrate |
| Formula | C61H107N3O6 |
| M.Wt | 978.52 |
| SMILES | O=C(OCCCCCCCC/C=C\C/C=C\CCCCC)CCCC1(CCCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)C=NC(C(OC(C)(C)C)=O)N1CCN2CCCCC2CC |
| Storage | Pure form: −20 °C for up to 1 year; stock aliquots at −20 °C up to 1 month unless otherwise specified on the vial. |
Literature formulation snapshot
IM: Lipid 331/DOPE/cholesterol/C14-PEG2000 = 35:16:46.5:2.5 mol%. IN: Lipid 331/DOTAP/cholesterol/C14-PEG2000 = 30:39:30:1 mol%.
Reported IM-LNP properties: 65.4 ± 0.8 nm, PDI 0.2, zeta −6.2 ± 1.7 mV, EE 75.0 ± 8.9%, apparent pKa 7.53 ± 0.17.
Important: N/P was not reported. The reported ionizable-lipid:mRNA mass ratio (10:1) is not an N/P ratio. The LNP component-mass calculator is disabled because C14-PEG2000 identity/MW is not sufficiently specified; the product page still provides a standalone Lipid 331 solution calculator using MW 978.52.
Source: Li et al., Nat Biomed Eng 2025;9:167–184, DOI 10.1038/s41551-023-01082-6.
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