HX1 — Datasheet
HX1 is a hydroxyzine-derived ionizable lipid with acetal-containing tails, studied in lipid nanoparticles for brain mRNA delivery and CRISPR–Cas9 delivery. It was the lead in the reported in vivo brain-delivery screen; evidence is preclinical and formulation-dependent.
| CAS No. | Not available |
| Chemical Name | HX1 |
| SMILES | CCCCCCOC(C)OCCCCCCN(CCCCCCOC(C)OCCCCCC)CCCCCC(=O)OCCOCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1 |
| Formula | C55H94ClN3O7 |
| M.Wt | 944.82 |
| Purity | To be confirmed; request batch COA |
| Storage | Confirm the supplied batch storage instructions; HX1-specific shelf life has not been established here. |
| Shipping condition | Contact us for current shipping conditions |
| Synonyms | HX-1, HX 1, Hydroxyzine-derived ionizable lipid HX1, HX1 lipid |
| Stereochemistry / form | Neutral parent as drawn; no counterion assigned. Three potentially stereogenic carbons are unspecified in the source; no single-isomer identity is claimed. |
| Publication | Meng Tian, Leiming Wang, Zhengwei Liu et al. Rational design of lipid nanoparticles for brain delivery of RNA therapeutics. Nature Nanotechnology (2026). DOI: 10.1038/s41565-026-02326-7 |
Formula and average molecular weight are calculated from the verified structure. The SI value 943.7 is consistent with monoisotopic mass; it is not the average molecular weight 944.82.
25 / 50 / 100 mg: request a quotation and synthesis assessment. Price, purity, availability and lead time require confirmation.